Systems and methods of cannulating a body orifice such as a bladder are disclosed. A cystoscopy catheter can include a proximal end, a distal end having at least one exit port, and a flexible elongate tubular body therebetween an inflatable balloon near the distal end of the catheter, the balloon transformable from an unexpanded and an expanded configuration a first proximal port for fluid inflow a second proximal port for fluid outflow a third proximal port for balloon inflation, in fluid connection with the balloon and a fourth proximal port for insertion of a diagnostic and/or therapeutic instrument such as a cystoscope therethrough, wherein the first, second, and fourth proximal ports are fluidly connected to a common central lumen extending through the elongate tubular body to the exit port on the distal end.
