EIDAM, HILARY SCHENCK,DEMARTINO, MICHAEL P.,GONG, ZHEN,GUAN, AMY HUIPING,RAHA, KAUSHIK,WU, CHENGDE,YANG, HAIYING,YU, HAIYU,ZHANG, ZHILIU,CHEUNG, MUI
申请号：
PE2015001878
公开号：
PE20151538A1
申请日:
2014.03.14
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
It refers to a compound determined according to formula (I),They are inhibitors of quintasa RET for the treatment of diffuse diseases and functional disorders: R1 is hydrogen, halogen, etc.； R2 is halogen, C1-C6 tar, etc.； R3 is phenyl, etc.； n is 0, 1 or 2. The most popular compounds are: 2 - (4 - (5-etoxi-6-oxo-1, 6-dihydropirin-3-il) - 2-fluorooffenil) - N - (6 - (2-hydroxypropane-2-il) - 5 - (trifluoromethyl) pyridine-3-il) acetyl, N - (6-etoxy-5 - (trifluoromethyl) pyridine-3-il) 2 - (4 - (5-etoxyxi-6-ox1, 6-pyr-pyridine-3) - ethyl acetyl acetyl ethyl othersSe refiere a un compuesto de acuerdo con la formula (I), los cuales son inhibidores de la quinasa RET, utiles para tratar enfermedades proliferativas, trastornos funcionales, etc, en donde: R1 es hidrogeno, halogeno, etc； R2 es halogeno, alquilo C1-C6, etc； R3 es fenilo, etc； n es 0, 1 o 2. Son compuestos preferidos: 2-(4-(5-etoxi-6-oxo-1,6-dihidropiridin-3-il)-2-fluorofenil)-N-(6-(2-hidroxipropan-2-il)-5-(trifluorometil)piridin-3-il)acetamida, N-(6-etoxi-5-(trifluorometil)piridin-3-il)2-(4-(5-etoxi-6-oxo-1,6-dihidropiridin-3-il)-2-fluorofenil)acetamida, entre otros
