NUEVOS DERIVADOS DE FOSFATO DE ISOQUINOLINILCARBONILFENIL INDOLIZINILO O FOSFATO DE ISOQUINOLINILCARBONILFENIL PIRROLILO SUSTITUIDOS, METÓDO PARA PREPARARLOS Y COMPOSICIONES FARMACÉUTICAS QUE LO CONTIENEN.
Thierry LE DIGUARHER,Olivier GENESTE,Jérôme-Benoît STARCK,Guillaume DE NANTEUIL,Anne-Françoise GUILLOUZIC,James Edward Paul DAVIDSON,James Brooke MURRAY,I-Jen CHEN,Arnaud LE TIRAN,Jean-Michel HENLIN
申请号：
MX2014008866
公开号：
MX351467B
申请日:
2014.07.22
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The invention relates to a compound of formula (I) wherein X, Y, A1 A2, Ra, Rb, Rc, Rd- R3- R4- T and R5 are as defined in the description. The compound of formula (I) is such that at least one of the carbon atoms constituting same is substituted by one of the following phosphate groups: -OPO(OM)(OM'), -???(??)(0'?1 +), -OPO(O"M1 + )(O~M2 +), -OPO(O")(O")M32 +, - OPO(OM)(O[CH2CH2O]nCH3), or -OPO(O"M1 +)(O[CH2CH2O]nCH3). The compounds exhibit an inhibiting activity in relation to anti-apoptotic proteins of the Bcl-2 family, allowing them to be used in pathologies involving an apoptosis defect, such as in the treatment of cancer, auto-immune diseases and the immune system.Compuestos de fórmula (I): (ver Fórmula) en la que X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T y R5 son tales como se han definido en la descripción.
