Methods for preventing and treating microbial infections by modulating transcription factors

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专利权人:

Paratek Pharmaceuticals; Inc.

发明人:

Alekshun, Michael N.,Levy, Stuart B.

申请号：

AU2012202095

公开号：

AU2012202095A1

申请日:

2012.04.12

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2012202095A120120503.pdf#####ABSTRACT The current invention is based, inter alia, on the finding that the transcription 5 factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other 10 virulence factors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/