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Generating induced pluripotent stem cells and progenitor cells from fibroblasts
专利权人:
Mickie Bhatia
发明人:
Mickie Bhatia,Eva Szabo,Shravanti Rampalli-Deshpande,Ruth Munoz Risueno
申请号:
US13504745
公开号:
US09340772B2
申请日:
2010.10.29
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor cells, without traversing the pluripotent state. Also provided is a method of isolating a subpopulation of fibroblasts with reprogramming potential comprising providing fibroblasts that express an Oct-4-reporter and isolating cells that are positive for the reporter. Further provided is a method of generating reprogrammed fibroblast-derived induced pluripotent stem cells. Also provided are uses and assays of the cells produced by the methods of the disclosure.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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