Composants d'homopipérazine qui inhibent le déphasage ribosomale en liaison à une structure de pseudonoeuds RNA de coronavirus SARS

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专利权人:

SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION

发明人:

申请号：

EP07123502.2

公开号：

EP1941885B1

申请日:

2007.12.18

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Provided is a homopiperazine compound for inhibiting ribosomal frameshifting by binding to an RNA pseudoknot structure of SARS coronavirus. Particularly, the present invention provides a pharmaceutical composition for inhibiting synthesis of protein induced by -1 frameshifting by binding to an RNA pseudoknot structure specifically existing in SARS coronavirus. The composition includes a therapeutically effective amount of homopiperazine compound of following chemical formula 1 or a pharmaceutically accepted salt thereof, and a pharmaceutically accepted carrier or excipient.

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