The present invention relates to a composition for skin regeneration, using a culture medium or a secretion in the culture of an embryonic stem cell-derived endothelial progenitor cell, and to the use thereof. As the present invention uses the secretion in the culture as a medicine and not the embryonic stem cell-derived endothelial progenitor cell itself, the risk of teratoma formation is prevented, and angiogenic activity is promoted to achieve improved effectiveness in healing wounds and burn wounds. The composition of the present invention, when used as a material in cosmetics, increases collagen synthesis and thus prevents skin aging. Particularly, the composition of the present invention in which the secretion in the culture is concentrated into a high concentration provides superior wound-healing effects as compared to a conventional human growth hormone (hGH).본 발명은 배아줄기세포 유래 혈관형성전구세포 배양액 또는 배양 분비물을 이용한 피부재생용 조성물 및 이의 용도에 관한 것으로, 본 발명은 배아줄기세포 유래 혈관형성전구세포 자체가 아닌 배양 분비물을 치료제로 이용하므로 기형종(teratoma) 형성의 위험성이 없고, 신생혈관 생성능력을 촉진시켜 창상치료, 화상창상치료에 효과적이며, 이를 화장품 원료로 이용하는 경우 콜라겐 생성을 증대시켜 피부노화를 방지하는 효과를 제공한다. 특히, 상기 배양 분비물을 고농도로 농축시킨 본 발명의 조성물은 종래 hGH(human growth hormone)에 비해 높은 창상치료효과를 제공한다.
