Disclosed is an infusion device drive unit (1). The infusion device drive unit (1) includes a pump drive, the pump drive being configured to operatively mechanically couple to a dosing unit (2) to control operation of the dosing unit (2). The infusion device drive unit further includes a blocking device (11), the blocking device (11) including at least one blocking member (110), the at least one blocking member (110) being movable between a blocking configuration and a enabling configuration, the at least one blocking member (110) enabling the establishing and/or the releasing of an operative mechanical coupling between the pump drive and the dosing unit (2) in the enabling configuration and preventing the establishing and/or the releasing of an operative mechanical coupling between the pump drive and the dosing unit (2) in the blocking configuration. The infusion device drive unit (1) is designed to control the at least one blocking member (110) to take on the enabling configuration if the pump drive is in at least one predetermined configuration and to take on the blocking configuration if the pump drive is in a configuration different from a pre-determined configuration.