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METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS
专利权人:
NGM BIOPHARMACEUTICALS INC.
发明人:
LING, LEI,LUO, JIAN,TIAN, HUI
申请号:
CA3082794
公开号:
CA3082794A1
申请日:
2016.11.08
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Provided herein are variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). In some embodiments, these variants and fusions modulate bile acid homeostasis, and are useful in treatment of bile acid related and associated disorders. In some embodiments, these variants and fusions have glucose lowering activity, and are useful in treatment of hyperglycemia and other disorders.
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