PROCÉDÉ D'ÉVALUATION DE LA DOULEUR CAUSÉE PAR L'ADMINISTRATION D'UNE SOLUTION DE MÉDICAMENT, PROCÉDÉ DE SÉLECTION D'ADMINISTRATION DE SOLUTION DE MÉDICAMENT
In a method for assessing pain caused by the administration of a drug solution, a rat (12) is provided, the rat (12) is anesthetized by inhalation anesthesia, a measurement electrode (24) is placed in the semitendinosus muscle (12b) of the anesthetized rat (12), an injection needle (18) is punctured under the plantar subcutaneous (12a) of the anesthetized rat (12) while measuring the myoelectric potential in the semitendinosus muscle (12b) with the measurement electrode (24), a drug solution is administered to the anesthetized rat (12) through the injection needle (18) after a myoelectric response caused by the punctuation of the injection needle (18) disappears, and at least one of the measurement of the duration time (T) of the myoelectric response caused by the administration of the drug solution and the measurement of the EMG intensity, which is produced by integrating absolute values of myoelectric potentials during the period between the onset of the myoelectric response by the administration of the drug solution to the disappearance of the myoelectric response, is carried out.
