SUBSTITUTED 4- ACRYLAMIDOPODOPHY LLOTOXIN CONGENERS AS ANTITUMOUR ANTIBIOTICS AND PROCESS FOR THE PREPARATION THEREOF
- 专利权人:
- 发明人:
- 申请号：
- IN2697/DEL/2010
- 公开号：
- IN293591B
- 申请日:
- 2010.11.11
- 申请国别(地区):
- IN
- 年份:
- 2018
- 代理人:
- 摘要：
The present invention provides compounds of general formula (3) as useful potential antitumour agents against human cancer cell lines. The present invention further provides a process for the synthesis of 4ß-acrylamidopodophyllotoxin congeners of general formula (3). wherein R and R1 are an aryl group and R is selected from 3, 4, 5-trimethoxyphenyl or 2-methoxy phenyl and R1 is selected from the group consisting of 4-hydroxy-3- methoxyphenyl, 3-hydroxy-4-methoxyphenyl, 4-fluoro-3-methoxyphenyl, 3-fluoro-4- methoxyphenyl, 2-fluoro-5-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 4-hydroxy-3- nitrophenyl, 4-methoxy-3-nitrophenyl, 4-nitrophenyl, 3-nitrophenyl, 2-nitro phenyl, 4- methoxyphenyl, 3-methoxyphenyl and 4-hydroxyphenyl.
[WO2012063250A1]
- 来源网站：
- 中国工程科技知识中心
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