ISE PROFESSIONAL TESTING & CONSULTING SERVICES INC
发明人:
申请号：
EP14737892.1
公开号：
EP2943209A1
申请日:
2014.01.09
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes. The resultant urodele-derived biomaterial can be used to enhance restoration of skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical inflammation, and to promote progression of natural healing and regeneration processes. In addition, the biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue.Le profil de facteurs de croissance, les constituants de la matrice de tissu conjonctif et le statut immunoprivilégié de la matrice extracellulaire (MEC) et du tissu conjonctif associé d'urodèle, ajoutés à la présence de peptides antimicrobiens, font du tissu dérivé d'urodèle une source idéale d'échafaudages biologiques pour la xénotransplantation. En particulier, un matériel biologique d'échafaudage biologique peut être obtenu par un procédé qui implique (A) l'obtention d'un échantillon de tissu sur un urodèle, le tissu comprenant la MEC, y compris la membrane basale, et (B) la soumission de l'échantillon de tissu à un processus de décellularisation qui mai
