The present invention relates to compositions and methods for the oral administration of sodium pentanoic polysulfate with improved bioavailability for the treatment of interstitial cystitis and other urinary tract diseases and conditions. With such compositions and methods, sodium pentosan polysulfate can be administered at low doses while reducing the frequency of administration and severe side effects. One aspect of the present invention is a pharmaceutical composition comprising (1) a therapeutically effective amount of sodium pentanoic polysulfate； (2) a penetration enhancer in an amount sufficient to enhance bioavailability of sodium pentanoic polysulfate； And (3) optionally, a pharmaceutically acceptable carrier. Another aspect of the present invention is a method for treating a disease, condition or syndrome associated with lower urinary tract dysfunctional epithelium (LUDE) or LUDE comprising: (1) a pharmaceutically effective amount of sodium pentanoic polysulfate； And (2) an amount of penetration effective to enhance bioavailability of sodium pentanoate polysulfate to a patient in need of treatment of a disease, condition or syndrome associated with LUDE or LUDE to treat a disease, condition or syndrome associated with LUDE or LUDE Orally administering the enhancer. Alternatively, the penetration enhancer may be used in combination with an agent selected from the group consisting of HIV infection, prostate cancer, osteoarthritis, rheumatoid arthritis, prion disease, inflammatory myocardial damage, osteonecrosis, degeneration of the intervertebral disc, amyloid-beta-induced toxicity in atherosclerosis, For the treatment of a disease or condition selected from the group consisting of psoriatic arthritis, psoriasis, psoriasis, psoriasis, and diseases.본 발명은 간질성 방광염 및 기타 요로 질환 및 병태의 치료를 위한 개선된 생체이용성을 갖는 소듐 펜토산 폴리설페이트의 경구 투여용 조성물 및 방법에 관한 것이다. 이러한 조성물과 방법에 의해 투여 빈도와 심한 부작용을 감소시키면서 낮은 투여량으로 소듐 펜토산 폴리설페이트를 투여할 수 있다. 본 발명의 일 측면은 (1) 소듐 펜토산 폴리설페이트의 치료적 유효량； (2) 소듐 펜
