Nigel G. Smith;Anthony M. Lowman;Kristin B. Kita;Garland W. Fussell
发明人:
Kristin B. Kita,Nigel G. Smith,Anthony M. Lowman,Garland W. Fussell
申请号：
US12812141
公开号：
US08366778B2
申请日:
2009.01.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.
