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APPLICATION OF HELIUM-OXYGEN GAS MIXTURES FOR TREATMENT OF PULMONARY ARTERIAL HYPERTENSION
专利权人:
БАЙЕР ШЕРИНГ ФАРМА АКЦИЕНГЕЗЕЛЬШАФТ (DE)
发明人:
ТРЮБЕЛЬ Хуберт (DE),БЕККЕР Эва-Мариа (DE),ШЭФЕР Штефан (DE),ШЭФЕР Катя (DE),КОЛЬМАЙЕР Юрген (DE)
申请号:
RU2011121520/15
公开号:
RU2011121520A
申请日:
2009.10.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Helium-oxygen gas mixture for the treatment of diseases. 2. The helium-oxygen gas mixture according to claim 1, having from 20 to 79% helium and from 80 to 21% oxygen. The helium-oxygen gas mixture according to claim 1 and 2 for use in a method for producing a medicament for the treatment and / or prevention of primary and secondary forms of pulmonary hypertension (LH). The use of helium-oxygen gas mixtures according to claim 1 and 2 for the manufacture of a medicament for the treatment and / or prevention of primary and secondary forms of pulmonary hypertension (LH). A drug containing a helium-oxygen gas mixture according to claim 1 and 2.6. A medicine containing a helium-oxygen gas mixture according to claim 1 and 2 in combination with an inert, non-toxic, pharmaceutically acceptable excipient. The helium-oxygen gas mixture according to claim 1 and 2 in combination with one or more drugs selected from the following group: - kinase inhibitors, in particular tyrosine kinase inhibitors such as those given as exemplary and preferred sorafenib, imatinib, gefitinib, or erlotinib, either nitric oxide (NO), or NO-independent, however heme-dependent, soluble guanylate cyclase stimulants, or NO-and heme-independent soluble guanylate cyclase activators, or prostacyclin analogues, such as those exemplified and edpochtitelnyh iloprost, beraprost, treprostinil or epoprostenol, or- endothelin receptor antagonists, such as actuated as exemplary and preferred bosentan, darusentan, ambrisentan or Sitaxentan, or- compounds which inhibit the cleavage of cyclic guanosine monophosphate (cGMP) and / or cyclic1. Гелий-кислородная газовая смесь для лечения заболеваний.2. Гелий-кислородная газовая смесь по п.1, имеющая в составе от 20 до 79% гелия и от 80 до 21% кислорода.3. Гелий-кислородная газовая смесь по п.1 и 2 для применения в способе получения лекарственного средства для лечения и/или профилактики первичной и вторичной форм легочной гипертонии (ЛГ).4. Применение гелий-кислородны
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