Disclosed is a medical tube fixing device, and more particularly a medical tube fixing device, which may ensure rapid coupling with a medical tube with minimal movement of the medical tube, and which includes a fixing member attached to a human body, the fixing member being flexibly operated in response to movement of the medical tube, thereby preventing deterioration in adhesive strength thereof. With provision of the medical tube fixing device, it is possible to rapidly fix or separate the medical tube to or from a desired portion of the human body, and to minimize movement of the fixing member caused during movement of the medical tube, thereby preventing deterioration in adhesive strength of the fixing member.