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pH-Modulated Formulations for Pulmonary Delivery
专利权人:
GRIFOLS; S.A.
发明人:
David C. Cipolla,Igor Gonda
申请号:
US16896132
公开号:
US20200297722A1
申请日:
2020.06.08
申请国别(地区):
US
年份:
2020
代理人:
摘要:
An aerosolizable formulation comprised of a drug, a carrier and pH affecting component is disclosed. The Drug is dissolved in the formulation at a concentration above which it remains in solution at neutral pH. This increases the concentration of the drug in solution making it possible to administer larger amounts of drug with the same or a smaller volume of formulation. When the formulation is aerosolized to small particles and inhaled into human lungs in small volumes (e.g. 0.05 to 0.5 mL) the fluids in the lungs neutralize the formulation causing the drug to participate out of solution. This results in the drug being delivered at a controlled rate below the rate at which drug is administered from a formulation initially at a neutral pH.
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