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Antigen-and-drug vehicle comprising synthetic peptide, and mucosal vaccine using the same
专利权人:
Hiroshi Kido
发明人:
Hiroshi Kido,Tsunetomo Takei,Dai Mizuno
申请号:
US12936075
公开号:
US08287887B2
申请日:
2009.03.30
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention is an antigen-and-drug (AD) vehicle and a mucosal vaccine utilizing a novel synthetic peptide. The antigen-and-drug (AD) vehicle is capable of inducing the production of secretory IgA antibodies, and is a complex of a synthetic peptide having the following amino acid sequence: PVHLKRLm (e.g., peptide of SEQ ID NO 1, 6, or 7) or KnLm (e.g., peptide of SEQ ID NO 2, 3, or 8), and a lipid(s). The mucosal vaccine is obtainable by allowing a mucosal-immunity-IgA-inducing amount of an antigen to coexist with, contact, be captured by, or be adsorbed onto the AD vehicle.
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