The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of an estetrol component at specified daily doses, optionally in combination with a progestogenic component. The therapy enjoys a statistically significant efficacy combined with a favourable profile for side effects compared to currently available methods for alleviating menopause-associated symptoms.本發明係涉及用於緩解絕經相關症狀的激素替代療法,且涉及相關的化合物與相關的包裝單元,其係基於以特定每日劑量向雌性哺乳動物施予雌四醇成分,且選擇性地與黃體酮類成分併用。相較於目前能用於緩解絕經相關症狀的方法,所述療法具有統計學上顯著的功效,且同時具有有利的副作用特徵。