CHEN, JUNG CHIH,陈荣治,陳榮治,LI, I CHIU,李怡萩,李怡萩,LI, KUN CHE,李坤澈,李坤澈,CHUANG, CHING CHENG,庄竞程,莊競程,KO, MEI LAN,柯美兰,柯美蘭,CHUANG, HAN CHIEN,庄涵茜,莊涵茜,CHIEN, MING HUNG,简铭宏,簡銘宏,WANG, YU RONG,王瑜蓉,王瑜蓉,WANG, HUNG RU,王鸿
申请号：
TW108110987
公开号：
TWI702971B
申请日:
2019.03.28
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The invention relates to color-changing eye drops for early screening Alzheimer's disease and an application thereof. The color-changing eye drops comprise 1 pg/ml-10 ng/ml of Aβ 42Aptamer-gold nanoparticles (AuNPs) and a pharmaceutically acceptable carrier or vehicle, which can be used to mix with the tears of a test subject to analyze the color change for determining the concentration proportion of Aβ 40:Aβ 42contained in the tears of the test subject. Accordingly, the present invention can be used for quickly screening whether the test subject has the prognostic of Alzheimer's disease, and has the advantages of low cost and convenience in use.本發明有關於一種篩檢阿茲海默症前兆之變色眼藥水及其應用，所述變色眼藥水係包括1 pg/ml∼10 ng/ml的 Aβ 42適體(Aptamer)-奈米金粒子(AuNPs)及其醫藥學上可接受之載劑或媒劑，將變色眼藥水與一受試個體之淚液混合，並分析變色眼藥水之顏色變化，以用於判定受試個體之淚液所含Aβ 40：Aβ 42濃度比例；藉此，本發明可被用以快速篩檢受試個體是否具有阿茲海默症前兆，並具有低成本、使用便利之功效。
