Interleukin-33 production inhibitor, and medicament, quasi-drug, cosmetic and food / drink composition for prevention, treatment or suppression of allergic diseases related to increase of interleukin-33
PROBLEM TO BE SOLVED: To provide a drug, a quasi drug, and a cosmetic which exert an excellent preventive, therapeutic, or suppressive effect on allergic diseases such as allergic rhinitis and atopic dermatitis based on the interleukin-33 (IL-33) production suppressing effect. Food and food and drink compositions. SOLUTION: An IL-33 production inhibitor containing 4'-demethylnobiletin as an active ingredient, and prevention and treatment of allergic diseases associated with an increase in IL-33 such as allergic rhinitis and atopic dermatitis. Alternatively, a pharmaceutical, quasi drug, cosmetic, and food / beverage composition for suppression are provided. Since 4'-demethylnobiletin is one of the metabolites of nobiletin, which is a citrus peel component that has been ingested for many years as a food component, the pharmaceutical composition, quasi drug, cosmetics or food / beverage composition of the present invention is safe. There is no risk of side effects. [Selection diagram]【課題】 インターロイキン－３３（IL-33）産生抑制作用に基づき、アレルギー性鼻炎やアトピー性皮膚炎などのアレルギー疾患に対し優れた予防、治療又は抑制効果を奏する医薬品、医薬部外品、化粧料、および飲食品組成物を開発すること。【解決手段】 ４’－デメチルノビレチンを有効成分として含有する、IL-33産生抑制剤、並びに、アレルギー性鼻炎、アトピー性皮膚炎などのIL-33の増加に関連するアレルギー疾患の予防、治療又は抑制用の医薬品、医薬部外品、化粧料、および飲食品組成物を提供する。４’－デメチルノビレチンは食品成分として長年摂取されてきたカンキツ果皮成分のノビレチンの代謝産物の一つであるため、本発明の医薬品、医薬部外品、化粧料又は飲食品組成物は安全性が高く副作用の心配がない。【選択図】 図１
