This invention provides pharmaceutical compositions comprising compounds including 5-phenylpenta-2,4-dienoic acid, 3-methyl-3-butenyl caffeic acid, 1,1-dimethylallyl caffeic acid, pinobanksin-3-acetate, tectochrysin, pinostrobin chalcone, benzyl ferulate and benzyl isoferulate. Methods of using such compositions, in particular in the treatment or prevention of gastrointestinal cancers, and the resensitisation of gastrointestinal cancers to therapy are also provided.本發明提供包含化合物的醫藥組合物,該化合物包括5-苯基戊烷-2,4-雙烯酸、3-甲基-3-丁烯基咖啡酸、1,1-二甲基烯丙基咖啡酸、松樹素-3-乙酸酯、甲金黃酮、球松素查耳酮、芐基阿魏酸酯以及芐基異阿魏酸酯;亦提供使用該組合物的方法,特別是用於腸胃道癌的治療或預防方法以及回復腸胃道癌對於治療的敏感性的方法。