Vitrisa Therapeutics, Inc.;Albert Einstein College of Medicine, Inc.
发明人:
Carl Erickson,Christopher P. Rusconi,Kevin G. McLure,Matthew Levy,Arijit Bhowmick
申请号：
US15990547
公开号：
US10428330B2
申请日:
2018.05.25
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.
