Suman Rakhit;Joanne Patman;Jailall Ramnauth;Paul Renton;Subhash C. Annedi;Shawn Maddaford
发明人:
Shawn Maddaford,Jailall Ramnauth,Suman Rakhit,Joanne Patman,Paul Renton,Subhash C. Annedi
申请号：
US13102705
公开号：
US08586620B2
申请日:
2011.05.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.
