BRYAN SORENSEN,RICHARD F. CLARK,AUGUSTINE T. OSUMA,ROBIN FREY,GEORGE DOHERTY,RAMZI F. SWEIS,MICHAEL L. CURTIN,MARINA A. PLIUSHCHEV,TODD M. HANSEN,KENTON LONGENECKER,MICHAEL R. MICHAELIDES,HOWARD R. HE
申请号：
ARP130101636
公开号：
AR091022A1
申请日:
2013.05.10
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compounds that inhibit the activity of nampt, compositions containing such compounds and Methods for treating diseases in which expresses the nampt.Claim 1: wherein is a compound of the formula (1) or a Salt thereof acceptable for Therapy.Where X is n or cy u00b9 independently； y u00b9 is selected among the group consisting of hydrogen, alkyl, alkoxy, haloalquilo, hidroxialquilo CN, o, F, CL, BR,And I r u00b9 independently selected among the group consisting nhr u00b3 NHC (OR), NHC (o) NH (ch u2082) u2098r u00b3 u02e3, ch u2082nhc nhr u00b3 NHC (OR), (OR) r u00b3, NHC (OR) (ch u2082) u2099r u00b3 C (o) NH (ch u2082 u2099r u00b3 (NHC), or u2098r u00b3 u02e3) (ch u2082), C (o) NH ( u2098r u00b3 u02e3, ch u2082)Ch u2082c nhr u00b3 ch u2082nhc and (OR), (OR) r u00b3； and Z is CH, C - C - C, F, CL, BR, c l o n； X is n or cy u00b9 independently； y u00b9 is selected among the group consisting of hydrogen, alkyl, alkoxy, haloalquilo,Hidroxialquilo Oh, CN, F, CL, BR, and R is Hydrogen； r u00b9, F, CL, Br or I； Z is cr u00b2； and R u00b2 independently selected among the group consisting nhr u00b3 NHC (OR), NHC (o) NH ( u2098r u00b3 u02e3, ch u2082)Ch u2082nhc nhr u00b3 NHC (OR), (OR) r u00b3, NHC (OR) (ch u2082) u2099r u00b3 C (o) NH (ch u2082) u2099r u00b3, NHC (OR) (ch u2082 u2098r u00b3 u02e3), C (o) NH (ch u2082) u2098r u00b3 u02e3 ch u2082c nhr u00b3 (,, OR)Ch u2082nhc r u00b3 and (OR)； and r u00b3 is selected independently between the phenyl heteroaryl group consisting of 5-6 members； where each r u00b3 phenyl is replaced with a replacement for the positionYente independently selected from the group consisting r u2074, or u2074, sr u2074, S (OR) r u2074, so u2082r u2074, r u2074 co C (OR), (OR) r u2074, OC (OC r u2074 or), (OR) or u2074, nh u2082, nhr u2074, N (r u2074) u2082, NHC (OR) r u2074 nr u2074c (, or) r u2074, NHS u2082r u2074 (OR), (OR) u2082r u2074, nr u2074sOr u2074 NHC (OR), (OR) or nr u2074c, NHC (OR) nh u2082, NHC (OR) nhr u2074, NHC (o) n (r u
