Manoharan, Muthiah,Maier, Martin,Jayaraman, Muthusamy,Matsuda, Shigeo,Jayaprakash, Narayanannair K.,Rajeev, Kallanthottathil G.,Akinc, Akin,Baillie, Thomas A.
申请号：
AU2016210739
公开号：
AU2016210739A1
申请日:
2016.08.05
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016210739A120160825.pdf#####H: grs Intrwovn NRPortbl DCC GRS 0646715_l.docx-5/08/2016 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS Abstract The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipid moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.WO 2011/153493 PCI/US2OI 1/039164 1/4 CC 6C OLC 'M0 --- vs (2/2U) O~je~jaDUD J~ll~da ... ... ... ... ... ... ... ... ... .. ..... ... .... .. ... .. . .... ... .
