Compositions and methods for enhancing Th1/Th17 cell responses and decreasing Th2 cell responses are disclosed herein. In various embodiments the present invention describes activation of human dendritic cells and enhancement of antigen-specific T cell responses in a Dectin-1-expressing human dendritic cells comprising an anti-Dectin-1-specific antibody or fragment thereof fused with one or more antigens. TLR2 ligands may also be included to enhance the activation and for enhancement of T-cell responses. Further, the invention also includes methods based on the compositions described herein for the treatment of pathogenic infections.本文揭示用於增進Th1/Th17細胞反應及降低Th2細胞反應之組合物及方法。在各實施例中,本發明闡述活化人類樹突細胞及增進表現德克汀-1(Dectin-1)之人類樹突細胞中抗原特異性T細胞反應,該等表現德克汀-1之人類樹突細胞包括與一或多種抗原融合之抗德克汀-1特異性抗體或其片段。亦可包含TLR2配體以增進該活化及增進T細胞反應。另外,本發明亦包含基於本文所述組合物來治療病原感染之方法。(無元件符號說明)
