The present disclosure is directed to an endoscopic surgical instrument and methods for performing a diverticulum treatment. The surgical instrument includes a handle assembly, an elongated member and a jaw assembly (30). The elongated member is operably coupled to the distal end of the handle assembly, while the jaw assembly is operably coupled to a distal end of the elongated member. The jaw assembly includes: a cartridge assembly (32)including a plurality of fasteners and a longitud inal slot defined therein an anvil having a fastener forming surface thereon, the cartridge assembly and anvil being mounted for movement with respect to one another between an open position and a closed position in close cooperative alignment for clamping tissue an actuation sled (140) supported within the cartridge assembly, the actuation sled being movable to urge the plurality of fasteners from the cartridge a knife blade (174) mounted to the actuation sled a drive beam (162) including a vertical support (172) strut and a cam member (180) supported on the vertical support strut, the cam member being positioned to translate relative to the anvil to maintain the anvil in the closed position during firing of the fasteners, the vertical support strut being positioned to abut the actuation sled and a drive screw (160) supported within the cartridge assembly, the drive screw having a threaded portion, wherein the drive beam is threadably coupled to the threaded portion of the drive screw such that rotation of the drive screw imparts longitudinal movement of the drive beam. The jaw assembly is configured to approximate an esophageal tract and a diverticulum.