Pengfei Zhou,Jing Zhang,Lingli Hu,Rui Wang,Xiang Zhou,Kesu Fan
申请号：
US15449656
公开号：
US10118964B2
申请日:
2017.03.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against a surface antigen CD3 of an immune cell the monovalent unit has a specific binding capability against a surface antigen HER2 of a tumor cell the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies.
