Provided is a needle removal operation cover with which a user can safely perform an injection needle removal operation even when a needle tip is directly inserted into the needle removal operation cover, and with which the user can remove the injection needle without requiring a wrist twisting motion. In a needle removal operation cover which is configured such that an injection needle which is detachably and threadedly mounted on a distal end of an injection cylinder is threadedly removed by rotating the injection needle, the needle removal operation cover is formed in a cylindrical shape such that a needle tube of the injection needle including a needle tip is accommodated in the needle removal operation cover and integral mounting of a needle hub in the needle removal operation cover is allowed, a flange body for a rotating operation is formed on a cylindrical outer peripheral surface in a projecting manner, an outer periphery of the flange body is formed of a plurality of continuous mountain-like ridge portions, and among the mountain-like ridge portions, the mountain-like ridge portions which correspond to a rotational direction along which the injection needle is released from the injection cylinder are formed into a shape which allows easy engagement of a finger for an operation with the ridge portions.