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תכשירים הכוללים דנדרימרים של dna הקשורים למולקולת sirna, שיטות הכנה ושימושים שלהן
专利权人:
GENISPHERE LLC
发明人:
申请号:
IL21084111
公开号:
IL210841A
申请日:
2011.01.24
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
The invention provides methods for protecting molecules from degradation in a bodily fluid like serum. In a first aspect, the method is for protecting a DNA dendrimer from degradation, and comprises the step of attaching the DNA dendrimer to a protein, digoxigenin, cholesterol, a primary amine, a hydrocarbon spacer of length of 3 to 120 carbons, a PEG molecule, biotin, a biotin derivative, fluorescein or a fluorescein derivative, or any combination thereof; thereby protecting the DNA dendrimer against nuclease degradation. In a second aspect, the method is for protecting a siRNA from degradation, comprising attaching the siRNA to a protected DNA dendrimer obtained in the first aspect; thereby protecting the siRNA against degradation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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