Xuefeng Ma;Li Yang;Kai Fan;Chun Zhang;Chunlan Hu;Xiang Mei;Hua Luo
发明人:
Chun Zhang,Kai Fan,Xuefeng Ma,Li Yang,Chunlan Hu,Hua Luo,Xiang Mei
申请号：
US13985273
公开号：
US09193967B2
申请日:
2012.02.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.
