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Expression system for modulating an immune response
专利权人:
Ian Hector Frazer;Julie Louise Dutton
发明人:
Ian Hector Frazer,Julie Louise Dutton
申请号:
US12738284
公开号:
US09593340B2
申请日:
2008.10.02
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower preference of usage by the mammal to confer the immune response than the codon it replaces.
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