ARIMURA, HIDETOSHI,TAKAHASHI, YOSHITAKE,YAMAUCHI, KOJI
申请号：
TW96123253
公开号：
TWI440651B
申请日:
2007.06.27
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Disclosed are: a safe bio-degradable/absorbable polymer having an extremely low metal catalyst content while retaining properties desired for a medical implant a process for the production of the polymer and a method for reducing the content of a metal catalyst in a bio-degradable/absorbable polymer, which can be applied on an industrial scale. Specifically, disclosed is a process for the production of a bio-degradable/absorbable polymer having a content of a metal catalyst of less than 1 ppm in terms of a metal, comprising the following steps (1) and (2): (1) copolymerizing lactide and &egr-caprolactone at a molar ratio ranging from 40/60 to 60/40 in the presence of a metal catalyst to produce a copolymer and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a ratio ranging from 25/75 to 45/55 by volume at a temperature lower than 40 DEG C, and then drying the copolymer. Also specifically disclosed is a process for the production of a bio-degradable/absorbable polymer having a content of a metal catalyst of less than 1 ppm in terms of a metal, comprising the following steps (1) and (2): (1) copolymerizing lactide and e-caprolactone at a molar ratio ranging from 65/35 to 85/15 in the presence of a metal catalyst to produce a copolymer and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a ratio ranging from 45/55 to 55/45 by volume at a temperature lower than 40 DEG C, and then drying the copolymer.
