CHAPPIE, THOMAS ALLEN,PATEL, NANDINI CHATURBHAI,VERHOEST, PATRICK ROBERT,HELAL, CHRISTOPHER JOHN,SCIABOLA, SIMONE,LACHAPELLE, ERIK ALPHIE,WAGER, TRAVIS T.,HAYWARD, MATTHEW MERRILL
申请号:
CA3015166
公开号:
CA3015166A1
申请日:
2017.02.15
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R2, R 3, and R 4are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.