Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd.;Hong Guan Ltd.
发明人:
Hongkui Deng,Yang Zhao,Ting Zhao,Jingyang Guan,Xu Zhang,Yao Fu,Junqing Ye
申请号：
US15780031
公开号：
US20190282624A1
申请日:
2015.11.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are chemical inducers of pluripotency (CIP) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists and S-adenosylhomocysteine hydrolase (SAH) inhibitors or histone acetylators. A method of inducing pluripotency in a partially or completely differentiated cell by using such chemical inducers of pluripotency is also provided. The method includes: (i) contacting a cell with the CIPs for a sufficient period of time to result in reprogramming the cell into a pluripotent stem cell having ESC-like characteristics (CiPSC). Isolated chemically induced pluripotent stem cells (CiPSCs) and their progeny, produced by inducing differentiation of the CiPSCs, can be used in a number of applications, including but not limited to cell therapy and tissue engineering.
