Disclosed is a recombinant canarypox vector comprising and capable of expressing in vivo in an animal host in need thereof: a) two, three or four genes, separately inserted into the C3 and C5 arms of the vector, and each gene encoding the same immunogenic polypeptide, which is selected from an influenza, an FMDV, a BTV, a PCV2, a PRRSV, a WNV, a Nipah virus, a Hendra virus, a leukemia virus, a leishmania virus, an FIV, an FIPV, a FCV, an AHSV, and a VSV polypeptide and b) an OX40L gene, inserted into the C6 arm of the vector, and encoding an OX40L polypeptide, which when expressed in vivo in an animal host functions as an adjuvant for the immunogenic polypeptide(s).
