NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)
发明人:
OTTERLEI, Marit
申请号：
EPEP2016/060231
公开号：
WO2016/177898A9
申请日:
2016.05.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5X6 (SEQ ID NO: 1 ) and wherein: X1 is a basic amino acid； X2 is an aromatic amino acid； X3 is an aromatic amino acid or a hydrophobic amino acid that has an R group comprising at least three carbon atoms； X4 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P)； X5 is any amino acid other than an acidic amino acid or an aromatic amino acid； and X6 is any amino acid other than an acidic amino acid or an aromatic amino acid, preferably a basic amino acid or Proline (P), wherein when X3 is not an aromatic amino acid, X5 is not lysine (K) and X6 is a basic amino acid or Proline (P)； or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and composition of the invention may be used as single agents. In other aspects of the invention the agents and composition may be used in conjunction with one or more additional active agents, such as kinase inhibitors.La présente invention concerne un agent, ou une composition contenant un agent, pour son utilisation dans le traitement ou la prévention de l'hypercytokinémie chez un sujet résultant de la libération de cytokine par des cellules immunitaires non-proliférantes dans le sang, ledit agent comprenant : (i) un composé oligopeptidique qui comprend un motif d'interaction avec PCNA et un domaine qui facilite l'absorption cellulaire de ce composé, dans lequel le motif d'interaction avec PCNA est X1X2X3X4X5X6 (SEQ ID NO :1 ) et dans lequel : X1 est un acide aminé basique； X2 est un acide aminé aromatique
