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転写産物の安定性と翻訳効率の向上をもたらすRNAの修飾
专利权人:
ビオエンテッヒ・アクチェンゲゼルシャフトBioNTech AG
发明人:
ウグール・サヒン,ジルケ・ホルトカンプ,エツレム・テューレツィ,ゼバスティアン・クライター
申请号:
JP20120154852
公开号:
JP6058928(B2)
申请日:
2012.07.10
申请国别(地区):
日本
年份:
2017
代理人:
摘要:
Nucleic acid molecule comprising (in 5'-3' transcription direction) (a) a promoter; (b) a transcriptable nucleic acid sequence or a nucleic acid sequence for inserting in to a transcriptable nucleic acid sequence; (c1) a first nucleic acid sequence, which corresponds to the 3'-non-translated region of a gene or is derived from it; and (c2) a second nucleic acid sequence, which corresponds to the 3'-non-translated region of a gene or is derived from it, is new. Independent claims are included for: (1) a nucleic acid molecule comprising (in 5'-3' transcription direction) (a) a promoter; (b) a transcriptable nucleic acid sequence or a nucleic acid sequence for inserting in to a transcriptable nucleic acid sequence; and (c) a nucleic acid sequence with a transcription under control of (a), where the nucleic acid sequence codes for a nucleotide sequence of at least 20 sequentially arranged A-nucleotide in the transcript; (2) a nucleic acid molecule obtained after linearization; (3) a RNA obtained by transcription,
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