BIEMANS, RALPH LEON,DUVIVIER, PIERRE,MAIRA-LITRAN, TOMAS
申请号：
CA2647455
公开号：
CA2647455C
申请日:
2007.03.29
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present application describes a process for conjugating a PNAG which is less than 40% N-acetylated to a carrier protein comprising the steps of a) activating the PNAG by adding a linker comprising a maleimide group to form an activated PNAG b) activating the carrier protein by adding a linker comprising a sulphydryl group to form an activated carrier protein and c) reacting the activated PNAG and the activated carrier protein to form a PNAG-carrier protein conjugate.
