Their preparation, their use as Medicines, and Drugs that comprise it.Claim 1: a compound of the formula (1) where a is an Aromatic Ring System of five to six members, which can contain 1 to 4 heteroatoms selected from Oxygen, nitrogen, and sulfur, where the Ring system is replaced once or more than once By R3,And where a Substituent on a nitrogen in a Heterocyclic Ring system may not be Halogen Halogen R3 each is independently cyano hydroxyl amino or - X3 X3 - R4 each is selected independently from a Link carbonyl Oxygen Sulphur - s or - S (-) 2 - AMI) or No,Which can be replaced by c1-4 alkyl, - C (o) - NH - and - C (o) - NH - each independently alkyl R4 is C1 - 6 Halo alkyl C1 - 6 cyano - C1 - 6 - hydroxy alkyl, alkoxyl alkyl C1 C1 - 4 - 6 C1 - alkyl amino alkyl C1 - 6 6 c1-4 alkyl amino alkyl C1 - 6 di - (c1-4 alkyl) - aminoalquilo C1 - 6 alkyd Enilo C2 - 6 Halo - alquenilo C2 C2 - 6 - 6 alquinilo Halo - alquinilo C2 C3 cycloalkyl - 6 - 6Where you can exchange a carbon Atom by Oxygen or amino, which in turn can be replaced by c1-4 alkyl, cycloalkyl and where C3 6 can bind directly to X3 or through a alquileno 2 C1 and C3, where cycloalkyl - 6 may in turn be replaced by H Allogenic, or c1-4 alkyl M is 0, 1, 2, 3, 4, 5 or 6 n is 0, 1, 2, 3, 45 or 6 each R1 or R2 is independently Halogen, alkyl 6 C1 -, Halo - C1 - C3 6 cycloalkyl alkyl, cycloalkyl - 7 pp. ISBN 7alquilo C1 C1 - alkoxyl - 4, 6, or Halo - alkoxyl - C1 - 6 X1 - C (o) -, and - X2 N - (L - B -) or - N (X1 - L - B and - x2) -, - C (o) - L - C (r6) 2 - R6 each is independently Hydrogen Geno, C1 - 6 alkyl alkyl, Halo - C1 - 6Cycloalkyl C3 - 7 7 - alkyl or cycloalkyl C1 - C3 - 4 or two R6 along with the carbon Atom to which they are United, form a cycloalkyl c3-4 b is a monocyclic Aromatic Ring System of five to six members or FUSED bicyclic Eight to ten members, which can contain 1 to 4 heteroatoms selected from Oxygen, nitrogen, and sulfurWhere the system of Ring can be replaced once or more than once for
