#$%^&*AU2011224089B220140417.pdf#####ABSTRACT Systems and methods introduce and deploy prosthesis into a blood vessel or hollow body organ by intra-vascular access. The prosthesis is secured in place by fasteners which 5 are implanted by an applier that is also deployed by intravascular access. The applier is configured to permit controlled, selective release of the fastener in a step that is independent of the step of implantation. 2828979_1 (GHMatters) P61617.AU.1 16/09/111/25 18 28 24 32 18 26-- 30 -10 24 3 26 32 46 14 46-12 11 466 214 Fig I 244 Fi.-2