Agents for treating, preventing or ameliorating diseases comprise a peroxisome proliferator-activator receptor activator selected from ketone compounds (I) - (V) or their salts or solvates, a hop extract or a modified hop extract. Agents for treating, preventing or ameliorating diseases comprise a peroxisome proliferator-activator receptor activator selected from ketone compounds of formula (I) - (V) or their salts or solvates, a hop extract or a modified hop extract. [Image] R 1>；, R 2>；, R 1>； 0>；, R 1>； 9>；1-6C alkyl or 2-6C alkenyl； R 3>；, R 4>；OH, 1-6C alkyl or 2-6C alkenyl； R 5>； - R 7>；, R 1>； 1>；, R 1>； 2>；, R 1>； 6>； - R 1>； 8>；H, 1-6C alkyl or 2-6C alkenyl； R 8>；, R 9>；H, OH, 1-6C alkyl, 2-6C alkenyl, COR 1>； 0>； or CH(OH)R 1>； 0>；； R 1>； 3>；, R 1>； 4>；OH, 1-6C alkyl, 2-6C alkenyl, COR 1>； 0>； or CH(OH)R 1>； 0>；； and provided that R 1>； and R 2>；, R 8>； and R 9>； and R 1>； 3>； and R 1>； 4>； are not both OH. An independent claim is also included for foods containing the agents. ACTIVITY : Anorectic； Antidiabetic； Antilipemic. In tests, administration of isohumulone at 0.5 weight% in the diet of C57BL/6 mice fed a high fat diet, significantly (by at least 5%) reduced blood cholesterol levels from 2 weeks. MECHANISM OF ACTION : PPAR-Agonist.
