MAURER, Dominik,ALTEN, Leonie,BUNK, Sebastian,MAURER DOMINIK,ALTEN LEONIE,BUNK SEBASTIAN
申请号：
CL2018002610
公开号：
CL2018002610A1
申请日:
2018.09.12
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
This description refers to T cell receptor (TCR) that bind to tumor Associated antigen (TAA) and that allow to recognize cancer cells specifically,To T lymphocytes expressing the same, Methods for producing the same, and Methods for treating cancers with the same.In particular, this description refers to several variants and their TCR molecules that bind to HLA Class I or II United with a Peptide product.As the igf2bp3 - 001 with the sequence of amino acids kiqeiltqv (SEQ ID no. 1).This description is concerned, in addition, peptides, Proteins, Nucleic acids and Cells for use in inmunoterapÉuticos methods.In particular, this description refers to Immunotherapy against cancer.This description refers, moreover, to epÍtopos peptÍdicos for T lymphocytes that are associated with Tumors, alone or in combination with other tumor Associated Peptides, e.g.Can be used as active ingredients in Pharmaceutical compositions, vaccines designed to stimulate antitumor immune responses.To stimulate or ex vivo T lymphocytes that later will be transferred to the patients.The peptides bound to Molecules of the major histocompatibility complex (MHC), or peptides as such can also be targets of Antibodies, T Lymphocyte receptor solubleUnion and other molecules.<；p>；LA PRESENTE DESCRIPCIÓ；N SE REFIERE A RECEPTORES DE LINFOCITO T (TCR) QUE SE UNEN A ANTÍ；GENOS ASOCIADOS A TUMOR (TAA) Y QUE PERMITEN RECONOCER ESPECÍ；FICAMENTE CÉ；LULAS CANCEROSAS, A LINFOCITOS T QUE EXPRESAN LOS MISMOS, A MÉ；TODOS PARA PRODUCIR LOS MISMOS, Y A MÉ；TODOS PARA TRATAR CÁ；NCERES CON LOS MISMOS. EN PARTICULAR, LA PRESENTE DESCRIPCIÓ；N SE REFIERE A VARIOS TCR Y A SUS VARIANTES QUE SE UNEN A MOLÉ；CULAS DE HLA DE CLASE I O II UNIDAS CON UN PÉ；PTIDO, COMO EL IGF2BP3-001 DOTADO DE LA SECUENCIA DE AMINOÁ；CIDOS KIQEILTQV (SEQ ID N.º； 1). LA PRESENTE DESCRIPCIÓ；N SE REFIERE, ADEMÁ；S, A PÉ；PTIDOS, PROTEÍ；NAS, Á；CIDOS NUCLE
