patent summary: "fc? riib specific fc antibody". The present invention relates to a polypeptide containing an fc region in which the activity of binding to both types of fcγria genetic polymorphism is maintained or reduced compared to that of a source polypeptide, and wherein fc? rib binding activity is increased compared to that of the source polypeptide； a pharmaceutical composition containing the polypeptide； a therapeutic or prophylactic agent for immune / inflammatory diseases, comprising the pharmaceutical composition； processes for the production of these products； and a method for maintaining or reducing the binding activity to both types of fcγri gene above mentioned polymorphism or increasing the fcγriib binding activity. Specifically, it was found that a polypeptide containing an antibody fc region containing a pro substitution mutation located at 238th position, as numbered according to the numbering method eu, by asp and a leu substitution mutation at 328th position, as numbered according to the numbering method eu, by glu is increased with respect to fc? riib binding activity and is maintained or reduced with respect to binding activity to both types of her de fc genetic polymorphism I laugh. It has also been found that a polypeptide containing an antibody fc region containing a pro substitution mutation located at 238th position, as numbered according to the numbering method eu, by asp and another type of mutation is increased relative to the fc? riib binding activity and is maintained or reduced with respect to the binding activity to both types of her de fc? riia genetic polymorphism. 1/1resumo patente de invenção: "anticorpo fc específico para fc?riib". a presente invenção refere-se a um polipeptídio contendo uma região fc em que a atividade de se ligar a ambos os tipos de polimorfismo genético h e r de fc?riia é mantida ou reduzida em comparação com a de um polipeptídio de origem, e em que a atividade de se ligar a fc?riib está aumentada em compar
