包含NKG2D結構域的多特異性嵌合受體及其使用方法农业专利-农业学术服务平台

发明人:: FAN, XIAOHU,范　晓虎,范　曉虎,WANG, JUN,王骏,王駿,WANG, PINGYAN,王平艳,王平豔,ZHUANG, QIUCHUAN,庄秋传,莊秋傳,MA. LIAN,马莲,馬蓮

摘要：: The present application provides chimeric receptors targeting NKG2D, and multispecific chimeric receptors comprising an NKG2D domain and a second antigen binding domain such as an IL-3 domain. Also provided are dual chimeric receptor systems comprising a first chimeric receptor comprising an NKG2D domain, and a second chimeric receptor comprising a second antigen binding domain such as an IL-3 domain. Further provided are engineered immune effector cells (such as T cells), pharmaceutical compositions, kits and methods of treating cancer.本申請提供靶向NKG2D的嵌合受體，和包含NKG2D結構域與和第二抗原結合結構域例如IL-3結構域的多特異性嵌合受體。還提供了雙嵌合受體系統，其包含包含NKG2D結構域的第一嵌合受體和包含第二抗原結合結構域例如IL-3結構域的第二嵌合受體。還提供了工程化免疫效應細胞（例如T細胞）、醫藥組合物、套組和治療癌症的方法。