SHA MI,R. BLAKE PEPINSKY,ZHAOHUI SHAO,CHRISTILYN P. GRAFF
申请号：
IN750/DELNP/2008
公开号：
IN261956B
申请日:
2008.01.28
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Endogenous Sp35 is a negative regulator for nenronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and ojigodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoina and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anli-Sp35 antibody.
