An Auto-Destruct, Pre-loaded Syringe is provided which is suitable for pre-loading with highly viscous, sticky and reactive drug and for withstanding higher pressure required for loading and deloading the viscous and sticky drug comprising a syringe body 1 having a lumen 2 therethrough characterized in that one end 3 of lumen being opposite to needle end 6 is provided with closing means 4, needle end 6 of lumen 2 is provided with closing means 7 comprising a glass bar 8 provided on its one side with a magnet bar 9, needle end 6 of lumen 2 and closing means 7 are covered with a cylindrical body 10 creating a cavity 11 around closing means 7, and cylindrical body 10 is provided on its end opposite to lumen 2 with a needle 12. In one embodiment, the present invention relates to An Auto-Destruct, Pre-loaded Syringe provided with actuator drive syringe.
