A micro-needle device is applicable for a target tissue with a first area having a first parameter and a second area having a second parameter. The micro-needle device includes a substrate and a micro-needle array connected to the substrate. The micro-needle array includes a first micro-needle corresponding to the first area and a second micro-needle corresponding to the second area. One of the surfaces of the substrate having the micro-needle array corresponds to the surface curvature of the target tissue. The first micro-needle has a first configuration corresponding to the first parameter, and the second micro-needle has a second configuration corresponding to the second parameter and different from the first configuration. The configuration includes at least one selected from a group consisting of length, distribution density, diameter, and medicine-carrying amount of micro-needle. A method for manufacturing a micro-needle device, and a method for manufacturing a micro-needle mold are also provided.一種微針元件，適用於一目標組織。目標組織包括具有第一區域參數的第一區域以及具有第二區域參數的第二區域。微針元件包括基板以及連接基板的微針陣列。微針陣列包括對應第一區域的第一微針與對應第二區域的第二微針。基板具有微針陣列的一面對應目標組織的組織表面的曲率。第一微針具有對應第一區域參數的第一組態，第二微針具有對應第二區域參數的第二組態，第一組態相異於第二組態。前述組態係選自由長度、分佈密度、直徑以及載藥量所組成的群組中的至少一者。本發明亦提供一種微針元件的製造方法以及一種微針模具的製造方法。
