The present invention provides a pharmaceutical liquid composition which includes sodium pico sulfate, magnesium oxide, citric acid and malic acid, and is physically and chemically stable. The dosage of the pharmaceutical liquid composition is 50-500 ml. The pH of the pharmaceutical liquid composition is 4.1-5.4. The pharmaceutical liquid composition includes a diluting agent and purified water. The diluting agent is selected from a group constituted by a pH adjusting agent, a stabilizer, a preservative, a sweetening agent and a flavoring agent.본 발명은 피코황산나트륨, 산화 마그네슘, 구연산 및 말산을 포함하고, 물리화학적으로 안정한 약학적 액제 조성물을 제공한다.